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Surgery MCQ 94

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Following Macroscopic type of Gastric Carcinoma is most common and has favorable prognosis:

A. Intestinal type
B. Diffuse type
C. Mixed type
D. Infiltrative type

Answer: A (S)

The Correct Answer is Intestinal type (REF)



Gastric cancer is the fifth most common type of cancer worldwide

Lauren classification of gastric adenocarcinoma

  • Intestinal type gastric carcinoma
    • Typically localized 
    • Polypoid, glandular formation
    • Similar to an ulcerative lesion with clear raised margins
    • Commonly located on the lesser curvature
  • Diffuse type gastric carcinoma 
    • No clear border 
    • Spreads earlier in the course of disease
    • Infiltrative growth
    • Diffuse spread in the gastric wall 
    • Linitis plastica: gastric wall thickening and leather bottle appearance
    • Composed of signet ring cells: round cells filled with mucin, with a flat nucleus in the cell periphery 
    • Associated with E-cadherin mutation
  • Intermediate type (the least common type): should be treated as the diffuse type, as the extent of tumor infiltration is difficult to assess



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