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Surgery MCQ 131

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Which one of the following drug must be stopped before performing assay for diagnosis of hyper-aldosteronism:


A. Spironolactone

B. Calcium channel blocker

C. Fluconazole

D. Oral contraceptive pills


The drug that needs to be stopped before performing an assay for diagnosis of hyper-aldosteronism is:


A. Spironolactone


Here's why:


  • Spironolactone is an aldosterone antagonist, which means it directly blocks the action of aldosterone. This can interfere with the accuracy of the test results, making it difficult to diagnose hyper-aldosteronism, a condition characterized by excessive aldosterone production.

  • Calcium channel blockers and Fluconazole do not directly affect the renin-angiotensin-aldosterone system (RAAS) and are generally not considered to significantly interfere with the tests for hyper-aldosteronism.

  • Oral contraceptive pills may influence the renin-angiotensin-aldosterone system in some individuals, but the effect is usually considered minimal and may not always require discontinuation before testing, depending on the specific test used and the individual's situation.

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